Correlations Between Hyperuricemia and Metabolic Syndrome

In recent years metabolic syndrome is a major worldwide health problem, affecting the population and the individual, both by increasing prevalence and the cardiovascular risk (CV) it determines. Gout and hypeuricemia may be associated with increased cardiovascular risk. Our study aims to evaluate the association of asymptomatic hyperuricemia and gout with cardiometabolic risk factors. We investigated the medical records of 153 patients hospitalized in the Rheumatology Clinic who fulfilled at least three of the five criteria defining the metabolic syndrome and were diagnosed with gout or asymptomatic hypeuricemia. Individuals were predominantly late middle aged, 50-59 years old. The number of male patients is significantly higher than the number of females. 74 patients have gout (48,4%) and 79 have asimptomatic hypeuricemia (51.6%). The frequency of hypertension was higher in patients with gout compared to those with hyperuricemia. Family history of cardiovascular disease was found in 55 patients, including 23 with gout and 32 with hyperuricemia. Moreover, hypercholesterolemia was present in 33 patients with gout and 44 patients with hyperuricemia. The increase above normal triglyceride values was ascertained in 36 patients with gout and 41 patients with hyperuricemia. Obesity was present in only 27 of the patients (13 with gout and 14 asymptomatic hyperuricemia). elevated ESR was found in 97 patients (47 with gout and hyperuricemia 50 with asymptomatic hyperuricemia), and the CRP increased in 40 patients (15 with gout and 25 asymptomatic hyperuricemia). We confirmed the previously reported sex-specific differences and the strong associations between serum uric acid concentration and age, obesity, hypertension, serum triglycerides levels, serum cholesterol levels, links between increased serum uric acid concentrations and the levels of the individual components of metabolic syndrome.